The aim of this study was to define the effects of Wnt and FGF4 on intestinal commitment in vitro by establishing conditions for differentiation of human pluripotent stem cells (hPSC) into posterior endoderm and further to self-renewing intestinal-like organoids.
The novel avenue of stem cell therapy and its potential role in the management of ulcerative colitis and Crohn's disease. We conducted a comprehensive literature search to identify studies examining the role of stem cell therapy in IBD.
Intramyocardial injection of hMPs improved cardiac function post-MI. The engraftment rate of these cells in the myocardium post-MI was low, suggesting that the majority of effect occurs via paracrine mechanisms.
We demonstrated that the neuronal cell-specific gene expression system induced over-expression of GM-CSF in NSCs. These combined NSCs-gene therapy treatment protocol would be an effective therapeutic system for SCI.
In this study, we collected embryonic fibroblasts from Cisd2-deficient embryos and reprogrammed them into induced pluripotent stem cells (iPSCs) via retroviral transduction with Oct4/Sox2/Klf4/c-Myc.
Journal of Stem Cells and Clinical Practice (JSCCP) is an open access journal devoted to publish high standard manuscripts focusing on the stem cell research covering all aspects of stem cells, including types of stem cells, developmental studies, stem cell transplantation, clinical applications and stem cell genome research. JSCCP encourages submissions of research works of academicians from all over the world.
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Journal of Stem Cells and Clinical Practice is using online manuscript submission, review and tracking systems for quality and quick review processing. Review processing is performed by the editorial board members of Journal of Stem Cells and Clinical Practice or outside experts; at least two independent reviewer's approval followed by editor approval is required for acceptance of any citable manuscript.