Annex Publishers

Introduction: Mental healthcare is moving toward de-institutionalization, focusing on community-based care. However, people with severe and persistent mental illness (SPMI) often require long-term, intensive support. The Oyster Care model, developed as an innovative approach based on palliative psychiatry, aims to address the complex needs of this population. This study seeks to develop and validate a monitoring tool for assessing the quality of care provided under the Oyster Care model

Background: In dermatological and pharmaceutical research ex vivo mouse skins are frequently used in topical drug deliv ery studies and analysis of skin diseases. One part of the experiments reported is carried out in hairless mouse skins, such as SKH1 nude mice, while others prefer the widely validated C57BL/6J hairy mice. However, in-depth characterization of the dermal barrier under healthy conditions has not been performed yet. In the current study tissue morphology, chemical com position, transepidermal water loss, and drug permeability were measured and compared at di erent anatomical regions in C57BL/6J and SKH1 mice

Background: For both endemic and non-endemic areas, Trypanosoma cruzi is the cause of Chagas disease, which can be life-threatening. Oversight: The entire life cycle of T. cruzi relies on the natural production of sterol through the 14-α demethylase metabolic pathway

Cancer patients face a markedly higher chances of venous thromboembolism (VTE), with the risk being four to seven times greater than individuals free of cancer. A strong association exists between cerebral metastasis and VTE, complicating treat ment due to an increased risk of bleeding. This case highlights the challenges of treating a 62-year-old man with advanced melanoma, worsened by retrobulbar lesion progression, eyeball herniation, VTE, and bleeding brain metastasis. Initially he was treated with immunotherapy, then by stereotactic radiotherapy at the retrobulbar lesion and second-line targeted thera py. A deep vein thrombosis in the left leg was treated with mechanical thromboaspiration and prophylactic dose of heparin. Unfortunately, a frontal brain metastasis hemorrhaged leading to heparin interruption. The case underscores the need for multidisciplinary approach in treating metastatic melanoma, highlighting the delicate balance between cancer treatment and managing complications in this complex setting.