Annex Publishers

Combining low-dose CT lung cancer screening (LCS) with smoking cessation has emerged as a next‐generation interven tion to reduce the human and societal burdens of lung cancer. is study reviews the evidence supporting both strate gies—individually and in combination—acknowledging that not all real-world smoking cessation interventions can be seam lessly integrated with LCS. While linking these strategies might enhance their respective primary endpoints, it is essential to ensure their integration does not inadvertently interfere with their individual outcomes. We present results of a survey on current best practices in the EU27 and propose key areas for further research. ese insights provide a foundation for future EU Commission-funded projects.

The anti-inflammatory activity of three samples of Indomethacin (IND-S1, IND-S2, IND-F) was evaluated in two models of acute inflammation (systemic and topical) and in the model of chronic inflammation. The three sample was solubilized in Tween 80:H2 O 1:9, was tested at 20 mg/kg and was administered by intragastric route. In first evaluation, the sample IN D-S1 at 20 mg/kg showed 57.09% inhibition on carrageenan-Induced plantar edema model. The evaluation at this same dose of Indomethacin from 3 different samples (IND-S1, IND-S2, IND-F) showed a variation in the % inhibition with 34.61, 30.13 and 32.69%, respectively. On the other hand; topical anti-inflammatory activity was evaluated in the TPA mod el acute in female Balb/C mice. IND-S1 showed an ED50 = 1.31 mg/ear and at a dose of 2 mg/ear showed 56.41% of inhibi tion. IND-S1, IND-S2 and IND-F at a dose of 2 mg/ear were more active with 87.39, 90.13 and 75.87%, respectively. In the chronic model of ear edema-TPA, when the IND-S1 was administered by i.g. route at 10 mg/kg, it showed high mortality (10/10), however at dose of 8 mg/kg, IND-S1 showed a 60.63% inhibition of ear edema, but in this assay 4/10 mice head. In same assay (TPA) but the IND was administered by topic route at repeated dose of 2 and 1 mg/ear, it cuased the death of all animals and at dose of 0.5 mg/ear caused about 50% of animals deaths

Tuberculosis is a worldwide health problem and is one of the 10 causes of death caused by a single infectious agent. It main ly affects the economically active population. Currently, there are multidrug-resistant and extended-resistance strains that are difficult to treat. In addition, several factors such as AIDS/HIV, diabetes, cancer and/or arthritis contribute to its persis tence, despite having first- and second-line drugs for its treatment. For this reason, it is necessary to contribute to find or search a new treatment alternatives and medicinal plants are an important source of bioactive compounds to be considered.

The present study has evaluated the effects of different inclusion levels of full fat black soldier fly (BSF) (Hermetia illucens L.) larva meal on the growth performance, carcass yield, organ development and gut pH of broiler chickens. A total of nine ty Cobb 500 broiler chicken of mixed sex were reared from day 21 to day 49 and assigned to 5 dietary treatments replicated thrice with 6 birds per replicate. The BSF larva meal was included at varied levels (0, 7.5%, 15%, 22.5% and 30%) in isoni trogenous and isoenergetic diets formulated for finisher feeding phase. One chicken per pen were slaughtered at day 49 for evaluation of carcass yield, organ development and gut pH. Data was analyzed using Statistical Analysis System software (SAS, 2009) and significant means were separated using Tukey Honest Significant Difference (HSD). The results showed that the total and weekly feed intake was not affected. Live, dressed, carcass weights, total weight gained, average daily weight gain showed a significant (P<0.05) quadratic response to BSF larvae meal to a maximum of 22.5% while feed conver sion ratio (FCR) and protein efficiency ratio (PER) was optimal at 15% inclusion level. The thigh and drumstick portion posted a significant (P<0.05) positive linear and quadratic respectively. In addition, the trial diets significantly affected the weight of the liver, spleen and gizzard