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Recent Articles

Factors Affecting Time to Return to a Normal Level of Hba1c Among Diabetes Mellitus Patients at Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia

Background: This study aims to fill the information gap on factors affecting time to return to normal HbA1c level and expected survival times in Ethiopia, as studies on these aspects are scarce, particularly in diabetic patients. Methods: A cross-sectional study was conducted on the patients with Diabetes Mellitus who follow-up the diabetic clinic at HUCSH, Ethiopia, between May to July 2021. The 382 diabetic patients were recruited into the study using simple random sam pling techniques from the recorded frame of the hospital and were interviewed using structured interview schedule. The Cox re gression analysis is applied on time to time to return normal HbA1c level. Data were entered, using EPI – info and analyzed by us ing STATA 16 computer software. Result: Diabetic patient expected survival times to return normal HbA1c had an average of 52.678 weeks with a standard error of 0.144. HbA1c level return to normal on patients of age below 18 year-old is reduced by 91.7% as compared to those who are older than 54 years. Similarly, the recovery time of patients in the age groups 18-36 year and 36-54 year is reduced by 44.1% and 55.6%, respectively compared to patients of age above 54 year-old. Moreover, when compared to patients with no medication side effects and patients with nausea/vomiting, headache, fatigue, and stomach upset have 43.8%, 57.3%, 44.1%, and 64.3% longer time to re turn to normal HbA1c level. Additionally, patient with low adherence level of patients were increased by 47.8 % time to return to normal HbA1c level compared to high adherence.

Bioequivalence Study of a Newly Developed Ibuprofen Arginine 600 Mg Tablet Formulation versus Ibuprofen Arginine 600 Mg Granules in Healthy Volunteers

Background and Objectives: A novel ibuprofen L-arginine film-coated tablet formulation has recently been developed. The study objective was to assess bioequivalence of the newly developed formulation and a marketed granules for oral solution (reference), in terms of rate and extent of absorption of S(+)-ibuprofen, R(-)-ibuprofen and their sum. Methods: In this randomized, two-way cross-over study, 24 healthy men and women received a single 600 mg oral dose of each product in 2 subsequent periods, with a washout of at least 3 days. Plasma S(+)- and R(-)-ibuprofen concentrations were determined with a chiral bioanalytical method up to 12 h post-dose, and total ibuprofen was calculated at each time- point as the sum of the two enantiomers’ concentrations. Pharmacokinetic parameters were determined. The primary study endpoints for bioequivalence evaluation were plasma peak concentration (Cmax ) and area under the curve up to the last time-point (AUC0–t )

A New Type of Anesthesia for Endovascular Abdominal Aortic Aneurysm Repair: 3 Cases Report

Choice of anesthetic approach for patients undergoing endovascular abdominal aortic aneurysm repair (EVAR) remains a challenge to the anesthetist, especially in emergency situations and for patients having multiple diseases. Although two main types of anesthetic techniques including general anesthetic (GA) and local anesthetic (LA) are used in EVAR, little is known about the effects of a combination method. Hence, we report a new combination anesthetic method used for 3 cases who are having multiple basic diseases (cardiovascular or lung) or with complex surgical procedure. The relevant anesthetic proce dure was firstly anesthesia induction with midazolam, sufentanil, etomidate, rocuronium and methylprednisolone. After in duction of GA and tracheal intubation, LA with 2% lidocaine combined with midazolam for sedation monitored anesthesia care (MAC) was maintained till to the end of the operation. Importantly, propofol and remifentanil were not injected with micropumps, muscle relaxants were not used, and anesthetics were not inhaled to maintain anesthesia. The depth of anesth esia was determined by Bis value and kept at the level of 40-60 during the operation. All patients cured and have completed one year follow-up. The benefits of using the method include: 1) increasing analgesic effect of LA mode and preventing pa tient body from moving and vasospasm occlusion caused by patient stress during LA procedure; 2) reducing the adverse re actions of GA drugs on cardiovascular and cerebrovascular systems therefore maintaining intraoperative hemodynamic sta bility. It is concluded that our method provides a new and valuable anesthetic consideration for emergency and complex en dovascular repair surgery

Recent Advances of Phytochemicals and Their Applications for Antiviral Therapy

Phytochemicals are chemicals produced by plants to serve as a defense against fungal, bacterial, and viral plant diseases. Currently, our world has encountered a plethora of frustrating viral infections. For most people’s morbidity and corporality, viral infections are primarily responsible. On the other hand, numerous plants’ secondary metabolites such as flavonoids, alkaloids, terpenes, po lyphenols and their derivatives have effective potentials to decline the multiplication of different viruses and have the capability to kill them. For instance, flavonoids can be used to treat novel corona virus, influenza A and others; phenols can be used to treat hu man papilloma virus, herpes and the likes. Understanding these secondary metabolites and their mechanism of actions against viruses is substantially insignificant.