1 Brownlee (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813-20

2 Matough FA, Budin SB, Hamid ZA, Alwahaibi N, Mohamed J (2012) The Role of Oxidative Stress and Antioxidants in Diabetic Complications. Sultan Qaboos Univ Med J. 12: 5-18.

3Facchini FS, Hua NW, Reaven GM, Stoohs RA (2000) Hyperinsulinemia: the missing link among oxidative stress and age-related diseases? Free Radical Biology and Medicine. 29: 1302-6.

4Grankvist K, Marklund SL, Täljedal IB (1981) CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse Biochem. J 199: 393-8.

5 Maritim AC, Sanders RA, Watkins JB (2003) Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol 17: 24-38.

6 Xu Q, Yuan F, Shen X, Wen H, Li W, et al. (2014) Polymorphisms of C242T and A640G in CYBA Gene and the Risk of Coronary Artery Disease: A Meta-Analysis. PLOS ONE. 9: e84251.

7 Wierusz-Wysocka B, Wysocki H, Byks H, Zozulińska D, Wykretowicz A, et al. (1995) Metabolic control quality and free radical activity in diabetic patients. Diabetes Res Clin Pract 27: 193-7.

8 Tang W, Jiang YF, Ponnusamy M, Diallo M (2014). Role of Nrf2 in chronic liver disease. World J. Gastroenterol 20: 13079-87.

9Sánchez-Valle V, Chávez-Tapia NC, Uribe M, Méndez-Sánchez N (2012) Role of oxidative stress and molecular changes in liver fibrosis: a review. Curr. Med. Chem 19: 4850-60.

10 Li AN, Li S, Zhang YJ, Xu XR, Chen YM, et al. (2014) Resources and biological activities of natural polyphenols. Nutrients 6: 6020-47.

11Feng Y, Wang N, Ye X, Li H, Feng Y, et al (2011) Hepatoprotective effect and its possible mechanism of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced chronic liver hepatotoxicity in rats. J Ethnopharmacol 138: 683-90.

12Pearlman M, Loomba R (2014) State of the art: treatment of nonalcoholic steatohepatitis. Curr Opin Gastroenterol 30: 223-37.

13 Akindele AJ, Adeyemi OO (2007) Anti-inflammatory activity of the aqueous leaf extract of Byrsocarpus coccineus. Fitoterapia 78: 25-8.

14 Ranzato E, Martinotti S Burlando B (2011) Wound healing properties of jojoba liquid wax: an in vitro study. J Ethnopharmacol 134: 443-9.

15 Elliger CA, Waiss AC, Lundin R (1973). Simmondsin, an unusual 2-cyanomethylenecyclohexyl glucoside from Simmondsia californica. J. Chem. Soc., Perkin Trans. 10, 2209-12

16 Boven MV, Holser RA, Cokelaere M, Decuypere E, Govaerts C,Lemey, et al. (2000). Characterization of triglycerides isolated from jojoba oil. J Amer Oil Chem Soc 77: 1325-29.

17Flo G, Van Boven M, Vermaut S, Decuypere E, Daenens P, et al. (1998) Effect of Simmondsin Derivatives on Food Intake: Dose− Response Curves in Rats. J Agri Food Chem 46: 1910-13.

18Wiseman MO, Price R L (1987) Characterization of protein concentrates of jojoba (Simondsia chinensis) meal. Cereal chemistry (USA) 2: 91-93.

19 Hultin E, Krogh A, Ogner, G, Guthrie C, Hinton M (1965) Alkaloid-screening of Plants from Boyce Thompson Southwestern Arboretum. Acta Chemica Scandinavica 19: 1297-1300.

20 Belhadj S, Hentati O, Hamdaoui G, Fakhreddine K, Maillard E, et al. (2018) Beneficial Effect of Jojoba Seed Extracts on Hyperglycemia-Induced Oxidative Stress in RINm5f Beta Cells. Nutrients 10: 384.

21 Belhadj S, Dal S, Khaskhoussi F, Maillard-Pedracini E, Hentati O, et al. (2020). Anorexic and metabolic effect of jojoba: potential treatment against metabolic syndrome and hepatic complications. Nutrition & Metabolism 17: 24.

22 Durand M, Molinier V, Kunz W, Aubry M (2011) Classification of Organic Solvents Revisited by Using the COSMO-RS Approach. Chem Eur J 17 : 5155-64.

23 Rabasso N (2009) Chimie organique, concepts et applications : Heteroelements et stratégies de synthese et chimie organométallique. 2eme Edition. Bruxelles; Paris: DE BOECK UNIVERSITE.

24 Bellirou A, Boual A, Bouammali B, Boukhatem N, Elmtili BN, et al. (2005) Extraction of simmondsin and oil in one step from jojoba seeds. Industrial Crops and Products 21: 229-33.

25 Cecchi G, Biasini S, Castano J (1985) Méthanolyse rapide des huiles en solvant: note de laboratoire. Revue francaise des corps gras 32: 163-4.

26 Turky GM, El-Adly R A (2017) Study of phase separation and anomalous molecular behavior of Jojoba oil using dielectric spectroscopy. Journal of Molecular Liquids 242: 1-7.

27 Sharp PB, (1974) An anthocyanin in Simmondsia chinensis: genetic and taxonomic implications. Available at: http://arizona. openrepository.com/arizona/handle/10150/554764 [Accessed July 2, 2017].

28 Abdel-Mageed WM, Bayoumi SAH, Radwa AA, Salem-Bekhit MM, Abd-Alrahman SH, et al. (2014) Simmondsia chinensis: A rich source of bioactive flavonoids and lignans. Industrial Crops and Products 60: 99-103.

29 Herman MA, Samuel VT (2016) The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis. Trends in Endocrinology & Metabolism 27: 719-30.

30 Azam S, Hadi N, Khan NU, Hadi SM (2004) Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3- gallate: implications for anticancer properties. Toxicol In Vitro 18: 555-61.

31 Yigitturk G, Acara AC, Erbas O, Oltulu F, Yavasoglu NUK, Uysal A (2017) The antioxidant role of agomelatine and gallic acid on oxidative stress in STZ induced type I diabetic rat testes. Biomedicine & Pharmacotherapy 87: 240-6.

32 Gerin F, Erman H, Erboga M, Sener U, Yilmaz A, et al. (2016) The Effects of Ferulic Acid Against Oxidative Stress and Inflammation in Formaldehyde-Induced Hepatotoxicity. Inflammation 39 :1377-86.

33 Shin DS, Kim KW, Chung HY, Yoon S, Moon JO (2013) Effect of sinapic acid against dimethylnitrosamine-induced hepatic fibrosis in rats. Archives of Pharmacal Research 36: 608-18.

34 El-Mallah MH, El-Shami SM (2009) Investigation of liquid wax components of Egyptian jojoba seeds. J Oleo Sci 58: 543-8.

35 Elmore S (2007) Apoptosis: A Review of Programmed Cell Death. Toxicol Pathol 35: 495-516.

36 Jaiswal N, Maurya C.K, Arha, D, Avisetti D.R, et al. (2015). Fructose induces mitochondrial dysfunction and triggers apoptosis in skeletal muscle cells by provoking oxidative stress. Apoptosis 20, 930-47. doi: 10.1007/s10495-015-1128-y.

37 Spencer JP, Schroeter H, Kuhnle G, Srai SK, Tyrrell RM, et al. (2001) Epicatechin and its in vivo metabolite, 3’-O-methyl epicatechin, protect human fibroblasts from oxidative-stress-induced cell death involving caspase-3 activation. Biochem J 354: 493- 500.

38 Incir S, Bolayirli IM, Inan O, Aydın MS, Bilgin IA, et al. (2016) The effects of genistein supplementation on fructose induced insulin resistance, oxidative stress and inflammation. Life Sciences 158: 57-62.

39Olaleye MT, Amobonye AE, Komolafe K Akinmoladun AC (2014) Protective effects of Parinari curatellifolia flavonoids against acetaminophen-induced hepatic necrosis in rats. Saudi Journal of Biological Sciences 21: 486-92.

40 Ramchandra PK, Shinde AV, Patil SM (2012). Lipid profile, serum malondialdehyde, superoxide dismutase in chronic kidney diseases and Type 2 diabetes mellitus. Biomedical Research 23: 207-10.

41 Borchi E, Bargelli V, Stillitano F, Giordano C, Sebastiani M, et al. (2010) Enhanced ROS production by NADPH oxidase is correlated to changes in antioxidant enzyme activity in human heart failure. Biochim. Biophys. Acta 1802: 331-8.

42 Cosentino F, Eto M, De Paolis P, Van der Loo B, Bachschmid M, et al. (2003) High glucose causes upregulation of cyclooxygenase-2 and alters prostanoid profile in human endothelial cells: role of protein kinase C and reactive oxygen species. Circulation 107: 1017- 23.

43 Feng X, Yu W, Li X, Zhou F, Zhang W, et al. (2017) Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. Biochem. Pharmacol 136: 136-149.

44 Sthijns MMJPE, Schiffers PM, Janssen GM, Lemmens KJA, Ides B, et al. (2017) Rutin protects against H2 O2 -triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells exposed to oxidative stress. Biochim. Biophys. Acta 1861: 1177-89.

45 Li C, Zhang WJ Frei B (2016) Quercetin inhibits LPS-induced adhesion molecule expression and oxidant production in human aortic endothelial cells by p38-mediated Nrf2 activation and antioxidant enzyme induction. Redox Biology 9: 104-13.

46 Martins IJ, Calderón de la Barca AM (2016) Diet and Nutrition reverse Type 3 Diabetes and Accelerated Aging linked to Global chronic diseases. J Diab Res Ther 2:2.

47 Martins IJ (2016) The role of clinical proteomics, lipidomics and genomics in the diagnosis of Alzheimer’s disease. Proteomes 4:14.

48Lu H, Chang Z, Han W, Wang L, Hong G (2014) Curcumin reduces paraquat-induced oxidative injury in A549 cells by activation of the Nrf2-ARE pathway. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 32:44-9.

49Ding YW, Zhao GJ, Li XL, Hong GL, Li MF, et al. (2016) SIRT1 exerts protective effects against paraquat-induced injury in mouse type II alveolar epithelial cells by deacetylating NRF2 in vitro. Int J Mol Med 37:1049-58.

50 Li S, Zhao G, Chen L, Ding Y, Lian J, et al.(2016) Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways. Mol Med Rep 13:1833-8.

51 Martins IJ (2016) Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations. Advances in Aging Research. 5: 9-26.

52 Martins IJ (2017) Nutrition Therapy Regulates Caffeine Metabolism with Relevance to NAFLD and Induction of Type 3 Diabetes. J Diabetes Metab Disord. 4: 019.

53 Martins IJ (2017) Single Gene Inactivation with Implications to Diabetes and Multiple Organ Dysfunction Syndrome. J Clin Epigenet 3:24.