Figure 1: Chemical structures of compounds 1-11

Compounds

Inhibition (%) in TG levels

0

3

10

30

100 (mM)

1

0.0 ± 1.6

5.9 ± 1.4

11.7 ± 1.3

15.6 ± 2.1*

18.1 ± 2.0*

2

0.0 ± 1.6

8.8 ± 1.2

18.6 ± 1.4*

26.4 ± 1.2**

35.9 ± 2.8**

3

0.0 ± 1.6

-2.5 ± 1.1

-4.6 ± 1.5

15.8 ± 2.1*

19.6 ±1.9*

4

0.0 ± 2.1

3.2 ± 1.8

5.6 ± 1.4

-8.2 ± 2.3

3.1 ± 1.4

5

0.0 ± 2.1

2.7 ± 1.6

6.8 ± 1.5

7.9 ± 2.1

15.6 ± 2.6*

6

0.0 ± 2.1

4.2 ± 2.3

8.1 ± 0.8

12.4 ± 0.6*

29.4 ± 1.2**

7

0.0 ± 1.3

5.1 ± 2.0

-6.9 ± 1.9

16.9 ± 2.6*

15.8 ± 2.3*

8

0.0 ± 1.3

2.5 ± 0.7

5.2 ± 1.3

3.2 ± 0.8

6.1 ± 0.6

9

0.0 ± 1.3

1.9 ± 1.5

2.3 ± 0.8

4.2 ± 1.3

3.6 ± 0.4

10

0.0 ± 0.6

3.9 ± 0.6

5.4 ± 1.1

6.8 ± 1.3

4.6 ± 1.4

11

0.0 ± 0.6

4.2 ± 1.4

-1.3 ± 0.6

12.6 ± 2.9

10.2 ± 1.2

Fenofibrate

0.0 ± 0.6

15.6 ± 1.2*

28.1 ± 0.9**

32.5 ± 2.1**

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