Figure 1: Fundus aspects: (A and B): Peau d’orange aspects in both eyes associated with serous retinal detachment and macular edema in the right eye and reticular pseudodrusen in the left eye; (C, D and E): Angioid streaks were around the papilla and spread in the centrifugal network. Subretinal fibrosis in the superior field of the right eye and the nasal field in the left eye as a yellow specked patch in connection with angioid streaks

Figure 2: Indocyanine green angiography (ICGA) and fluorescein angiography (FA): (A and B): Early phase: Choroidal neovascularization was clearly visible in ICGA and FA in the right eye. Subretinal fibrosis showed hypofluorescent aspects in ICGA while it was hyperfluorescent in FA as angioid streaks; (C and D) Late phase: A hypofluorescent aspect in the posterior pole was noted in both eyes but was more important in the right eye and contrasted with hyperfluorescence of angioid streaks and subretinal fibrosis

Figure 3: OCT-Spectral domain and OCT-angiography: (A, B and C): Indirect signs of the CNV were visible in the OCT-spectral domain in the right eye while the CNV were clearly visible in OCT-A taking the shape of a sea-fan in connection with the retro-epithelial part which is associated with the angioid streaks. In the B-Scan, the yellow spots represent the projection of the vascular flow detected in OCT-A. The blue arrow shows the unbroken BM while the orange arrow indicates its interruption. In the left eye, no macular anomaly was noted except for the presence of pseudoreticular drusens in the supero-temporal field; (D and E): Subretinal fibrosis appears as an hyper-reflective subretinal deposits between the outer retinal region and BM that appears in OCT-A as a homogenous vascular network in connection with AS. Here also, the blue arrow shows the unbroken BM while the orange arrow shows its interruption