Editorial Board Member - JSCCP
Zhiyuan Li
ProfessorLaboratory of Ion Channels Research
Guangzhou Institute of Biomedicine and Health
Chinese Academy of Sciences
China
BIOGRAPHY:
Dr. Zhiyuan Li is working as Principal Investigator in Laboratory of Ion Channels Research at Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, china. He completed his Ph.D. in Pharmacology Department at Central South University, China and in Nutrition Department at Tokushima University, Japan. He was a Post-doctoral Fellow at Pharmacology Department at Vanderbilt University, US. He also worked as Professor, Sheng-Hua Scholar, Director of Anatomy and Neurobiology, Xiang-Ya School of Medicine, Central South University. He received several awards and grants. He authored many articles, books, abstracts and book chapters.
RESEARCH INTERESTS:
Dr. Zhiyuan Li’s research is focused on cell membrane ion channels with electrophysiological method patch clamp technique. Regarding the stem cells differentiation, to increase its efficiency and examined the effects of Kv1.3 channel. Kv1.3 specific blocker Psora-4, a small molecule, could improve the efficiency of NSC neuronal differentiation. It also increased the percentage of mature-like neurons. Ion channels crucial roles in pathological processing. The efficient generation of human iPSCs from SMA, Parkinson’s, LNS and Nav mutant epilepsy patients, and then systemically recorded ion channels properties on these differentiated functional neurons. The results demonstrate that iPSCs-derived neurons exhibited a hyperexcitable state. More importantly, patient iPSCs-derived neurons can recapitulate the neuronal pathophysiology and respond to drug treatment, indicating that these neurons can be potentially used for screening appropriate drugs for personalized therapies.
Other Editorial Board Members - JSCCP
Ki Baik Hahm
Cancer Prevention Research Center
CHA University
Korea
Xiaoyan Jiang
Department of Medical Genetics
University of British Colombia
Canada
Inbo Han
Department of Neurosurgery
CHA University
South Korea
Gianluca Vadala
Department of Orthopaedic and Trauma Surgery
Campus Bio-Medico University of Rome
Italy
Ren-Ke Li
Laboratory Medicine and Pathobiology
University of Toronto
Canada
Abdolreza Esmaeilzadeh
Department of Immunology
Cancer Gene Therapy Research Center
Zanjan University of Medical Sciences
Iran
Marc Poirot
Cancer Research Center of Toulouse
University of Toulouse
France
Li-Ru Zhao
Department of Neurosurgery SUNY Upstate Medical University
United States
Nils Ole Schmidt
Department of Neurosurgery
University Medical Center Hamburg-Eppendorf
Germany
Massimo Dominici
Head Laboratory of Cell Biology and Advanced Cancer Therapies
Department of Medical and Surgical Sciences for Children & Adults
University Hospital of Modena and Reggio Emilia
Italy