Journal of Immunology and Infectious Diseases

Dr. Paula M Chilton received her Ph.D in 1996 from the University of Louisville studying the control of soluble IL-4R expression with Dr. Rafael Fernandez-Botran. Several postdoctoral research positions followed, including one at the University of Pennsylvania School of Veterinary Medicine with Drs. Phillip A. Scott and Raymond W. Sweeney studying the early immune response to Mycobacterium avium ssp paratuberculosis, and one studying mixed chimerism as a cure for type I diabetes in NOD mice with Dr. Suzanne Ildstad at the Institute for Cellular Therapeutics at the University of Louisville. As a research scientist, Dr. Chilton studied T cell function and survival during effective vaccination using low-toxicity TLR agonists as adjuvants with Dr. Thomas Mitchell, also at the Institute for Cellular Therapeutics. In 2009, Dr. Chilton joined the Department of Microbiology & Immunology as an Assistant Professor in the Department of Microbiology & Immunology and continues to work at the Institute for Cellular Therapeutics at the University of Louisville School of Medicine.

• Effects of low-toxicity TLR-based adjuvants on T cell differentiation, function and survival
• Vaccination and the induction of T cell memory
• The function of low-toxicity TLR4 agonists in the control of immune cell activation